Anybody have a writeup on HMG?
- Thread starter sabres1
- Start date
Supreme Sports
Banned
HMG Massone
HMG is used for stimulating hormones by triggering FSH and LH production in the body. This drug was originally designed for use in women where it stimulates the ovaries to produce multiple follicles, thus making them more fertile. The dosage varies from woman to woman, and HMG has been shown to induce ovulation in about 75-85% of patients that it is administered to.
In men, HMG can be used to stimulate natural testosterone production and to keep or restore the natural function of the testes. Those using HMG after testicular dystrophy often report an increase in sex drive and sense of well being as well as an increased rebound in fertility.
HMG is a drug similar to hcg in use and some of its function, but also has the added benefit of FSH stimulation, which triggers extra receptors to produce testosterone. While hcg is known mainly for testicular stimulation, HMG will also increase the amount of sperm the body is producing, which hcg isn’t as effective at. Although it hasn't been around as long and isn't as recognized as hcg, HMG is steadily picking up more interest in the medical community for the roles it can play in testosterone recovery. Those who don't see the results and recovery they want from a typical PCT protocol may find HMG beneficial since it is able to stimulate the body's receptors at a wider range of points than hcg is able to.
HMG can be most effective when ran alongside other LH stimulating drugs such as hcg, Clomiphene, and Tamoxifen during a post cycle treatment plan. A typical dose of 75-150iu a day for 2 weeks is sufficient for restoring normal testicular function and sperm count in males. Although some may find that a longer protocol is needed due to extended periods of staying shut down or the use of hormones which are harsher on the body's natural testosterone function such as such as Trenbolone etc. One may also wish to run an anti-estrogen such as Aromasin during administration of this drug due to the possibility of elevated estrogen levels.
HMG is used for stimulating hormones by triggering FSH and LH production in the body. This drug was originally designed for use in women where it stimulates the ovaries to produce multiple follicles, thus making them more fertile. The dosage varies from woman to woman, and HMG has been shown to induce ovulation in about 75-85% of patients that it is administered to.
In men, HMG can be used to stimulate natural testosterone production and to keep or restore the natural function of the testes. Those using HMG after testicular dystrophy often report an increase in sex drive and sense of well being as well as an increased rebound in fertility.
HMG is a drug similar to hcg in use and some of its function, but also has the added benefit of FSH stimulation, which triggers extra receptors to produce testosterone. While hcg is known mainly for testicular stimulation, HMG will also increase the amount of sperm the body is producing, which hcg isn’t as effective at. Although it hasn't been around as long and isn't as recognized as hcg, HMG is steadily picking up more interest in the medical community for the roles it can play in testosterone recovery. Those who don't see the results and recovery they want from a typical PCT protocol may find HMG beneficial since it is able to stimulate the body's receptors at a wider range of points than hcg is able to.
HMG can be most effective when ran alongside other LH stimulating drugs such as hcg, Clomiphene, and Tamoxifen during a post cycle treatment plan. A typical dose of 75-150iu a day for 2 weeks is sufficient for restoring normal testicular function and sperm count in males. Although some may find that a longer protocol is needed due to extended periods of staying shut down or the use of hormones which are harsher on the body's natural testosterone function such as such as Trenbolone etc. One may also wish to run an anti-estrogen such as Aromasin during administration of this drug due to the possibility of elevated estrogen levels.
stbizzle
Active member
This thread is courtesy of a knowlegdable bro on another board. Hes discovered that for some people that have done long cycles, or high dosed cycles with the harsher compounds, HCG and clomid won't cut it, but the addition of HMG will bring one back to somewhat normal if not better. enjoy!
By Cyphon:
HMG is typically used to treat infertility . Basically, long term use of HCG at doses of 1000 i.u. 3 or more times weekly causes suppresion or insensitivity of Luetinizing hormone (LH) and to some degree Follicle stimulating hormone (FSH).
Body builders who dont respond to the classic PCT schemes of low dose HCG and clomid for a few weeks will definitley have a hard time with recovery and may encounter depression, a lacking sexual drive, low testicular weight along with low semen/sperm volume.
HMG is Follicle stimulating hormone (FSH) and luetinizing hormone (LH). This simply stimulates your natural test production and keeps HCG working optimally. Your sex drive and sense of well being come back more rapidly then with other treatmentsr as well as your potential for staying or becoming fertile.
Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are called gonadotropins because stimulate the gonads - in males, the testes, and in females, the ovaries. They are not necessary for life, but are essential for reproduction. These two hormones are secreted from cells in the anterior pituitary called gonadotrophs. Most gonadotrophs secrete only LH or FSH, but some appear to secrete both hormones.
As described for thyroid-simulating hormone, LH and FSH are large glycoproteins composed of alpha and beta subunits. The alpha subunit is identical in all three of these anterior pituitary hormones, while the beta subunit is unique and endows each hormone with the ability to bind its own receptor.
In both sexes, LH stimulates secretion of sex steroids from the gonads. In the testes, LH binds to receptors on Leydig cells, stimulating synthesis and secretion of testosterone. Theca cells in the ovary respond to LH stimulation by secretion of testosterone, which is converted into estrogen by adjacent granulosa cells.
As its name implies, FSH stimulates the maturation of ovarian follicles. Administration of FSH to humans and animals induces "superovulation", or development of more than the usual number of mature follicles and hence, an increased number of mature gametes.
FSH is also critical for sperm production. It supports the function of Sertoli cells, which in turn support many aspects of sperm cell maturation.
Diminished secretion of LH or FSH can result in failure of gonadal function (hypogonadism). This condition is typically manifest in males as failure in production of normal numbers of sperm. In females, cessation of reproductive cycles is commonly observed.
Elevated blood levels of gonadotropins usually reflect lack of steroid negative feedback. Removal of the gonads from either males or females, as is commonly done to animals, leads to persistent elevation in LH and FSH. In humans, excessive secretion of FSH and/or LH most commonly the result of gonadal failure or pituitary tumors. In general, elevated levels of gonadotropins per se have no biological effect.
Heres a quick study:
Ten typical cases of male eunuchoidism (two with anosmia) are reported. After administration of clomifene citrate to five patients, there is no change in blood levels of gonadotrophins in four cases; in the fifth, a small and transitory increase of LH is noted. The intravenous injection of LHRH (100 mug) to five patients induces an increase of serum LH in all cases and serum FSH in three cases. The initial site of the dysfunction is possibly hypothalamic with secondary gonadotrophic pituitary insufficiency. Among six patients anxious for paternity, prolonged treatment (for 36 to 98 weeks), with HCG (250-1 000 I.U. daily) +HMG (65-120 I.U. FSH daily) results in appearance of spermatozoa in the seminal fluid in five cases and a pregnancy was obtained in four cases. Comments are done upon methods of treatment."
"Ten typical cases of male eunuchoidism (two with anosmia) are reported. After administration of clomifene citrate to five patients there was no change in blood levels of gonadotrophins in four cases; in the fifth, a small and transitory increase of LH was noted. The intravenous injection of LHRH (100 mcg) to five patients induced an increase of serum LH in all cases and serum FSH in three cases. The initial site of the dysfunction is possibly hypothalamic with secondary gonadotrophic pituitary insufficiency. Among six patients desiring paternity, prolonged treatment (for 36 to 98 weeks), with HCG(1700-7000 I.U. weekly) + HMG (450-825 I.U. FSG weekly) resulted in the appearance of spermatozoa in the seminal fluid in five cases and a pregnancy was obtained in four cases. Methods of treatment are discussed."
"Although testosterone (T) therapy is sufficient for maturation and maintenance of secondary sex characteristics in hypogonadal men, gonadotropins are required for stimulation of spermatogenesis. Thirteen men with hypogonadotropic hypogonadism received treatment with hCG, followed in 12 by the addition of human menopausal gonadotropin (hMG). All initially had undetectable serum LH and FSH and low T levels and were azoospermic with small testes. During therapy, all achieved normal male levels of T. Twelve of 13 had marked and continuous increase in testicular volume. Three men had sperm in the ejaculate with hCG treatment alone. All but 1 patient developed sperm in their seminal fluid during combined hCG and hMG therapy. Two men achieved three pregnancies, and 2 more had semen that produced hamster oocyte penetration assays in the fertile range during the protocol period. Four of 5 who achieved sperm densities greater than 1 million/ml while receiving combined therapy maintained or increased sperm production while receiving continued hCG therapy after hMG was withdrawn. We examined the response to gonadotropin therapy of men who had received previous T therapy and those who had not. There were no differences in rapidity or degree of response, as assessed by rise in serum T, increase in testis volume, or maximal sperm density achieved. Multiple pituitary deficits and cryptorchidism were negative prognostic factors. In summary, the prognosis for successful stimulation of spermatogenesis in men with hypogonadotropic hypogonadism treated with hCG/hMG is good and not adversely affected by prior androgen treatment. Despite undetectable serum FSH levels, hCG treatment was sufficient to both initiate and maintain spermatogenesis in some patients."
HMG most commenly comes in 75 i.u. ampules. They work Sub-Q as well as I.M.
Whether your shut down hard or just looking for more effective PCT You should always begine with the lowest most effective dose and work from there.
My regimen was simple:
1000 I.U. HCG three times weekly
75 I.U. HMG Three times weekly
50mg clomid daily
Obviously many studies have shown a variation in HCG/HMG doses. I would always advise to start low. A fertility study used a protocol of 2500 I.U. HCG + 300 I.U. HMG two times per week.
Depending on your goals this treatment can last 1-2 years ( for fertility and total recovery). For Bodybuilders who simply want a quick PCT protocol they can run this 4 weeks.
Obviously if your planning on going back on a cycle in a short time this wouldnt be something youd wanna stay on for months.
I believe it still can be an effective short term PCT program and replace your existing protocol if you do plan on running cycles more than two times a year.
I shot the HCG and HMG on the same days with different stick. I used BA for both.
Results are spectacular. Increase in testicle size and weight. Increase semen output. The most important of all.......A sense of well being and normalcy.
I havent had time to research much but the stuff works and thats all you really need to know.
By Cyphon:
HMG is typically used to treat infertility . Basically, long term use of HCG at doses of 1000 i.u. 3 or more times weekly causes suppresion or insensitivity of Luetinizing hormone (LH) and to some degree Follicle stimulating hormone (FSH).
Body builders who dont respond to the classic PCT schemes of low dose HCG and clomid for a few weeks will definitley have a hard time with recovery and may encounter depression, a lacking sexual drive, low testicular weight along with low semen/sperm volume.
HMG is Follicle stimulating hormone (FSH) and luetinizing hormone (LH). This simply stimulates your natural test production and keeps HCG working optimally. Your sex drive and sense of well being come back more rapidly then with other treatmentsr as well as your potential for staying or becoming fertile.
Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are called gonadotropins because stimulate the gonads - in males, the testes, and in females, the ovaries. They are not necessary for life, but are essential for reproduction. These two hormones are secreted from cells in the anterior pituitary called gonadotrophs. Most gonadotrophs secrete only LH or FSH, but some appear to secrete both hormones.
As described for thyroid-simulating hormone, LH and FSH are large glycoproteins composed of alpha and beta subunits. The alpha subunit is identical in all three of these anterior pituitary hormones, while the beta subunit is unique and endows each hormone with the ability to bind its own receptor.
In both sexes, LH stimulates secretion of sex steroids from the gonads. In the testes, LH binds to receptors on Leydig cells, stimulating synthesis and secretion of testosterone. Theca cells in the ovary respond to LH stimulation by secretion of testosterone, which is converted into estrogen by adjacent granulosa cells.
As its name implies, FSH stimulates the maturation of ovarian follicles. Administration of FSH to humans and animals induces "superovulation", or development of more than the usual number of mature follicles and hence, an increased number of mature gametes.
FSH is also critical for sperm production. It supports the function of Sertoli cells, which in turn support many aspects of sperm cell maturation.
Diminished secretion of LH or FSH can result in failure of gonadal function (hypogonadism). This condition is typically manifest in males as failure in production of normal numbers of sperm. In females, cessation of reproductive cycles is commonly observed.
Elevated blood levels of gonadotropins usually reflect lack of steroid negative feedback. Removal of the gonads from either males or females, as is commonly done to animals, leads to persistent elevation in LH and FSH. In humans, excessive secretion of FSH and/or LH most commonly the result of gonadal failure or pituitary tumors. In general, elevated levels of gonadotropins per se have no biological effect.
Heres a quick study:
Ten typical cases of male eunuchoidism (two with anosmia) are reported. After administration of clomifene citrate to five patients, there is no change in blood levels of gonadotrophins in four cases; in the fifth, a small and transitory increase of LH is noted. The intravenous injection of LHRH (100 mug) to five patients induces an increase of serum LH in all cases and serum FSH in three cases. The initial site of the dysfunction is possibly hypothalamic with secondary gonadotrophic pituitary insufficiency. Among six patients anxious for paternity, prolonged treatment (for 36 to 98 weeks), with HCG (250-1 000 I.U. daily) +HMG (65-120 I.U. FSH daily) results in appearance of spermatozoa in the seminal fluid in five cases and a pregnancy was obtained in four cases. Comments are done upon methods of treatment."
"Ten typical cases of male eunuchoidism (two with anosmia) are reported. After administration of clomifene citrate to five patients there was no change in blood levels of gonadotrophins in four cases; in the fifth, a small and transitory increase of LH was noted. The intravenous injection of LHRH (100 mcg) to five patients induced an increase of serum LH in all cases and serum FSH in three cases. The initial site of the dysfunction is possibly hypothalamic with secondary gonadotrophic pituitary insufficiency. Among six patients desiring paternity, prolonged treatment (for 36 to 98 weeks), with HCG(1700-7000 I.U. weekly) + HMG (450-825 I.U. FSG weekly) resulted in the appearance of spermatozoa in the seminal fluid in five cases and a pregnancy was obtained in four cases. Methods of treatment are discussed."
"Although testosterone (T) therapy is sufficient for maturation and maintenance of secondary sex characteristics in hypogonadal men, gonadotropins are required for stimulation of spermatogenesis. Thirteen men with hypogonadotropic hypogonadism received treatment with hCG, followed in 12 by the addition of human menopausal gonadotropin (hMG). All initially had undetectable serum LH and FSH and low T levels and were azoospermic with small testes. During therapy, all achieved normal male levels of T. Twelve of 13 had marked and continuous increase in testicular volume. Three men had sperm in the ejaculate with hCG treatment alone. All but 1 patient developed sperm in their seminal fluid during combined hCG and hMG therapy. Two men achieved three pregnancies, and 2 more had semen that produced hamster oocyte penetration assays in the fertile range during the protocol period. Four of 5 who achieved sperm densities greater than 1 million/ml while receiving combined therapy maintained or increased sperm production while receiving continued hCG therapy after hMG was withdrawn. We examined the response to gonadotropin therapy of men who had received previous T therapy and those who had not. There were no differences in rapidity or degree of response, as assessed by rise in serum T, increase in testis volume, or maximal sperm density achieved. Multiple pituitary deficits and cryptorchidism were negative prognostic factors. In summary, the prognosis for successful stimulation of spermatogenesis in men with hypogonadotropic hypogonadism treated with hCG/hMG is good and not adversely affected by prior androgen treatment. Despite undetectable serum FSH levels, hCG treatment was sufficient to both initiate and maintain spermatogenesis in some patients."
HMG most commenly comes in 75 i.u. ampules. They work Sub-Q as well as I.M.
Whether your shut down hard or just looking for more effective PCT You should always begine with the lowest most effective dose and work from there.
My regimen was simple:
1000 I.U. HCG three times weekly
75 I.U. HMG Three times weekly
50mg clomid daily
Obviously many studies have shown a variation in HCG/HMG doses. I would always advise to start low. A fertility study used a protocol of 2500 I.U. HCG + 300 I.U. HMG two times per week.
Depending on your goals this treatment can last 1-2 years ( for fertility and total recovery). For Bodybuilders who simply want a quick PCT protocol they can run this 4 weeks.
Obviously if your planning on going back on a cycle in a short time this wouldnt be something youd wanna stay on for months.
I believe it still can be an effective short term PCT program and replace your existing protocol if you do plan on running cycles more than two times a year.
I shot the HCG and HMG on the same days with different stick. I used BA for both.
Results are spectacular. Increase in testicle size and weight. Increase semen output. The most important of all.......A sense of well being and normalcy.
I havent had time to research much but the stuff works and thats all you really need to know.
basskiller
New member
I'm sure the price will come down as time goes on.
I am i right to assume that this can be used as a standalone? So far the material i have read has it being used along with HCG.
jediclampet
New member
It works great without hcg.
Hmg
HOWDY GUYS;
i´ve used hcg and hmg for therapy for quite a while. the results were less than favourable. the better alternative comes in form of a nasal spray by the brandname "KRYPTOCUR". this spray does the job of hcg and hmg much much better and is really easy to use. check for that... i am friends with chris clark, he´s done a write-up on hormonal recovery some years ago for RX-MUSCLE, Dave Palumbos MAG: i´ll see if we can post this one here on OLM, its a pretty good read!
regards, robc299
HOWDY GUYS;
i´ve used hcg and hmg for therapy for quite a while. the results were less than favourable. the better alternative comes in form of a nasal spray by the brandname "KRYPTOCUR". this spray does the job of hcg and hmg much much better and is really easy to use. check for that... i am friends with chris clark, he´s done a write-up on hormonal recovery some years ago for RX-MUSCLE, Dave Palumbos MAG: i´ll see if we can post this one here on OLM, its a pretty good read!
regards, robc299
galaxy
New member
75ius to 150ius ed for two weeks to keep the hcg working better is all I know
P
pinkpanthar
Guest
Is HCG neccesary to use WITH this stuff?
galaxy
New member
In male fertility cases it is only used when hcg fails to do the job. So really, the question should be is hmg really neccesary to be used with hcg?
P
pinkpanthar
Guest
bigtasty21
Member
I think if your pretty well shutdown u might as well just use both in lower doses. Im doing 75iu of hmg daily for 12 days (in 2 doses)...and 10 days of hcg at 500iu daily (split in 3 doses throughout the day)..with a little letro for bloat, and 50mg clomid for extra hpta restoration...will let u all know how it goes...im on day 3 so far with the HMG and notice sperm increase...and balls feel a little more plump already...and i do know on friday (1st day of use)..i felt unusually strong in the gym..so good so far
P
pinkpanthar
Guest
I think if your pretty well shutdown u might as well just use both in lower doses. Im doing 75iu of hmg daily for 12 days (in 2 doses)...and 10 days of hcg at 500iu daily (split in 3 doses throughout the day)..with a little letro for bloat, and 50mg clomid for extra hpta restoration...will let u all know how it goes...im on day 3 so far with the HMG and notice sperm increase...and balls feel a little more plump already...and i do know on friday (1st day of use)..i felt unusually strong in the gym..so good so far
You're going to run a PCT after though, right?
bigtasty21
Member
Run a PCT after i do HCG/HMG? hmg/hcg arent steroids..lol...but i will continue using clomid...and get some bloodwork done a week after i do the hcg/hmg so i can see where my free test..lh and fsh are at..
my free test was only 33ng/dl before so it can only go up from there ;-p
my free test was only 33ng/dl before so it can only go up from there ;-p